Type 2 diabetes, obesity, growth & reproductive ageing genetics

TYPE 2 DIABETES & OBESITY

Below you can find links to our main publications covering type 2 diabetes and related traits including obesity. This work is led by Profs Tim Frayling and Michael Weedon and Drs Andrew Wood, Hanieh Yaghootkar, Marcus Tuke, Sam Jones and Jess Tyrrell

2017

Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, Joost S, Guessous I, Murray A, Strachan DP, Kutalik Z, Weedon MN, Frayling TM.
Gene-obesogenic environment interactions in the UK Biobank study.
Int J Epidemiol. 2017 Jan 10

2016

Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, Tuke MA, Ruth KS, Pearson ER, Murray A, Freathy RM, Munroe PB, Hayward C, Palmer C, Weedon MN, Pankow JS, Frayling TM, Kutalik Z.
Quantifying the extent to which index event biases influence large genetic association studies.
Hum Mol Genet. 2016 Dec 30.

Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS; GIANT consortium, Yaghootkar H, Freathy RM, Murray A, Frayling TM, Weedon MN.
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
Diabetologia. 2016 Mar 10. [Epub ahead of print] PubMed PMID: 26961502.

Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, Wood AR, Murray A, Weedon MN, Frayling TM.
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.
BMJ. 2016 Mar 8;352:i582. PubMed Central PMCID: PMC4783516.

2015


Fall T, Xie W, Poon W, Yaghootkar H, Mägi R; GENESIS consortium, Knowles JW, Lyssenko V, Weedon M, Frayling TM*, Ingelsson E.

Using genetic variants to assess the relationship between circulating lipids and type 2 diabetes.
Diabetes. 2015 May 6.

Joshua W. Knowles, Weijia Xie*, Zhongyang Zhang, Indumathi Chennemsetty, Themistocles L. Assimes, Jussi Paananen, Ola Hansson, James Pankow, Mark O. Goodarzi, Ivan Carcamo-Orive, Andrew P. Morris, Yii-Der I. Chen, Ville-Petteri Mäkinen, Andrea Ganna, Anubha Mahajan, Xiuqing Guo, Fahim Abbasi, Danielle M. Greenawalt, Pek Lum, Cliona Molony, Lars Lind, Cecilia Lindgren, Leslie J. Raffel, Philip S. Tsao, The RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) consortium, The EUGENE2 (European network on Functional Genomics of Type 2 Diabetes) study, The GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) consortium, The SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and IR) study, Eric E. Schadt, Jerome I. Rotter, Alan Sinaiko, Gerald Reaven, Xia Yang, Chao A. Hsiung, Leif Groop, Heather J. Cordell, Markku Laakso, Ke Hao, Erik Ingelsson, Timothy M. Frayling, Michael N. Weedon, Mark Walker and Thomas Quertermous
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Journal Of Clinical Investigation 2015

Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, ~100 other authors Wareham NJ, Waterworth DM, Boerwinkle E, Kao WH, Florez JC, Loos RJ,Wilson JG, Frayling TM, Siscovick DS, Dupuis J, Rotter JI, Meigs JB, Scott RA, Goodarzi MO.
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Nat Commun. 2015 Jan 29;6:5897. PubMed Central PMCID: PMC4311266.

Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, Lawlor DA, Davey Smith G, Jørgensen T, Hansen T, Pedersen O, Steinthorsdottir V, Guðbjartsson DF, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Hattersley AT, Walker M, Morris AD, McCarthy MI, Palmer CN, Laakso M, Frayling TM.
Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion.
Diabetes. 2015 Jun;64(6):2279-85

Usher CL, Handsaker RE, Esko T, Tuke MA, Weedon MN, Hastie AR, Cao H, Moon JE, Kashin S, Fuchsberger C, Metspalu A, Pato CN, Pato MT, McCarthy MI, Boehnke M, Altshuler DM, Frayling TM, Hirschhorn JN, McCarroll SA.
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.
Nat Genet. 2015 Aug;47(8):921-5Epub 2015 Jun 22. PubMed Central PMCID: PMC4712930.

2014

Frayling TM. Commentary
Statins and type 2 diabetes: genetic studies on target.
Lancet.2014 Sep 24. pii: S0140-6736(14)61639-1. PMID: 25262342.

Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF,Dastani Z, Richards JB, Semple RK, Frayling TM.
Genetic evidence for a normal-weight “metabolically obese” phenotype linking insulin resistance,hypertension, coronary artery disease and type 2 diabetes.
Diabetes. 2014 Jul 21. PMID: 25048195.

Frayling TM, Hattersley AT. Commentary
Physiology helps GWAS take a step closer to mechanism.
Diabetes. 2014 Jun;63(6):1836-7. PMID: 24853896.

2013

Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM.
Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study.
Int J Epidemiol. 2013 Dec;42(6):1714-23. PMID: 24336895; PMCID: PMC3887570.

Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, El Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kähönen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Häring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U; the GENESIS consortium; the RISC consortium, Lehtimäki T, Liu CT, Loos RJ, McCarthy MI, Morris AD, Vasan RS, Spector TD, Teslovich TM, Tuomilehto J, Willems van Dijk K, Viikari JS, Zhu N, Langenberg C, Ingelsson E, Semple RK, Sinaiko AR, Palmer CN, Walker M, Lam KS, Paulweber B, Mohlke KL, van Duijn C, Raitakari OT, Bidulescu A, Wareham NJ, Laakso M, Waterworth DM, Lawlor DA, Meigs JB, Richards JB, Frayling TM.
Mendelian Randomisation Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes.
Diabetes. 2013 Oct;62(10):3589-98.] PubMed PMID: 23835345.

Yaghootkar H, Frayling TM. Review
Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits.
Genome Biol. 2013 Mar 28;14(3):203. PMC3663087.

Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M; MAGIC Investigators; DIAGRAM Consortium; GENESIS Consortium; RISC Consortium, Dekker JM, Nolan JJ, Groop L, Ferrannini E, Adam KP, Gall WE, Frayling TM, Walker M.
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Diabetes. 2013 Jun;62(6):2141-50. PubMed PMID:23378610; PubMed Central PMCID: PMC3661655.

Horikoshi M, Yaghootkar H,

2012

Frayling TM. Are the causes of obesity primarily environmental? No. Commentary
BMJ. 2012 Sep 11;345:e5844. PubMed PMID: 22968529.
Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, Steinthorsdottir V, Scott RA, Almgren P, Arking DE, Aulchenko Y,Balkau B, Benediktsson R, Bergman RN, Boerwinkle E, Bonnycastle L, Burtt NP,Campbell H, Charpentier G, Collins FS, Gieger C, Green T, Hadjadj S, Hattersley AT, Herder C, Hofman A, Johnson AD, Kottgen A, Kraft P, Labrune Y, Langenberg C, Manning AK, Mohlke KL, Morris AP, Oostra B, Pankow J, Petersen AK, Pramstaller PP, Prokopenko I, Rathmann W, Rayner W, Roden M, Rudan I, Rybin D, Scott LJ, Sigurdsson G, Sladek R, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Uitterlinden AG, Vivequin S, Weedon MN, Wright AF; MAGIC; DIAGRAM Consortium; GIANT Consortium, Hu FB, Illig T, Kao L, Meigs JB, Wilson JF, Stefansson K, van Duijn C, Altschuler D, Morris AD, Boehnke M, McCarthy MI, Froguel P, Palmer CN, Wareham NJ, Groop L, Frayling TM*, Cauchi S*.
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases.
PLoS Genet. 2012 May;8(5):e1002741. Epub 2012 May31. PMCID: PMC3364960.

Islam M, Jafar TH, Wood AR, De Silva NM, Caulfield M, Chaturvedi N, Frayling TM.
Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis.
Diabetologia. 2012 Apr 28. PubMed PMID: 22538361.

Warren LL, Li L, Nelson MR, Ehm MG, Shen J, Fraser DJ, Aponte JL, Nangle KL, Slater AJ, Woollard PM, Hall MD, Topp SD, Yuan X, Cardon LR, Chissoe SL, Mooser V, Morris AD, Palmer CN, Perry JR, Frayling TM, Whittaker JC, Waterworth DM.
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Diabetes. 2012 May;61(5):1297-301. Epub 2012 Mar 8. PMCID: PMC3331741.

2011

Edghill EL, Khamis A, Weedon MN, Walker M, Hitman GA, McCarthy MI, Owen KR, Ellard S, T Hattersley A, Frayling TM.
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Diabet Med. 2011 Jun;28(6):681-4.. PMID: 21569088.

Frayling TM, Ong K. Commentary
Piecing together the FTO jigsaw.
Genome Biol. 2011 Feb
24;12(2):104. PMID: 21349207.

Rees SD, Islam M, Hydrie MZ, Chaudhary B, Bellary S, Hashmi S, O’Hare JP, Kumar S, Sanghera DK, Chaturvedi N, Barnett AH, Shera AS, Weedon MN, Basit A, Frayling TM, Kelly MA, Jafar TH.
An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference.
Diabet Med. 2011 Jun;28(6):673-80 PMCID:PMC3095685.

De Silva NM, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN, Shields B, Knight BA, Ward KJ, Sandhu MS, Harbord RM, McCarthy MI, Smith GD, Ebrahim S, Hattersley AT, Wareham N, Lawlor DA, Morris AD, Palmer CN, Frayling TM.
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
Diabetes. 2011 Mar;60(3):1008-18. PMCID: PMC3046819.

2010

Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, Warrington NM, Widen E, Hottenga JJ, Kaakinen M, Lange LA, Bradfield JP, Kerkhof M, Marsh JA, Mägi R, Chen CM, Lyon HN, Kirin M, Adair LS, Aulchenko YS, Bennett AJ, Borja JB, Bouatia-Naji N, Charoen P, Coin LJ, Cousminer DL, de Geus EJ, Deloukas P, Elliott P, Evans DM, Froguel P; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Glaser B, Groves CJ, Hartikainen AL, Hassanali N, Hirschhorn JN, Hofman A, Holly JM, Hyppönen E, Kanoni S, Knight BA, Laitinen J, Lindgren CM; Meta-Analyses of Glucose and Insulin-related traits Consortium, McArdle WL, O’Reilly PF, Pennell CE, Postma DS, Pouta A, Ramasamy A, Rayner NW, Ring SM, Rivadeneira F, Shields BM, Strachan DP, Surakka I, Taanila A, Tiesler C, Uitterlinden AG, van Duijn CM; Wellcome Trust Case Control Consortium, Wijga AH, Willemsen G, Zhang H, Zhao J, Wilson JF, Steegers EA, Hattersley AT, Eriksson JG, Peltonen L, Mohlke KL, Grant SF, Hakonarson H, Koppelman GH, Dedoussis GV, Heinrich J, Gillman MW, Palmer LJ, Frayling TM, Boomsma DI, Davey Smith G, Power C, Jaddoe VW, Jarvelin MR; Early Growth Genetics (EGG) Consortium, McCarthy MI.
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nat Genet. 2010 May;42(5):430-5. PMCID: PMC2862164.

De Silva NM, Frayling TM. Review
Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits.
Curr Opin Lipidol. 2010 Feb;21(1):44-50. PMID: 19956073.

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H, Ferrucci L, Maggio M, Paolisso G, Walker M, Palmer CN, Payne F, Young E, Herder C, Narisu N, Morken MA, Bonnycastle LL, Owen KR, Shields B, Knight B, Bennett A, Groves CJ, Ruokonen A, Jarvelin MR, Pearson E, Pascoe L, Ferrannini E, Bornstein SR, Stringham HM, Scott LJ, Kuusisto J, Nilsson P, Neptin M, Gjesing AP, Pisinger C, Lauritzen T, Sandbaek A, Sampson M, Zeggini ME, Lindgren CM, Steinthorsdottir V, Thorsteinsdottir U, Hansen T, Schwarz P, Illig T, Laakso M, Stefansson K, Morris AD, Groop L, Pedersen O, Boehnke M, Barroso I, Wareham NJ, Hattersley AT, McCarthy MI, Frayling TM.
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2
diabetes.
Hum Mol Genet. 2010 Feb 1;19(3):535-44. PMCID: PMC2798726.

Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Raeder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN.
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes. 2010 Jan;59(1):266-71. PMCID: PMC2797932.

2009

Perry JR, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, Rice N, Melzer D; DIAGRAM Consortium, Saxena R, Scott LJ, McCarthy MI, Hattersley AT, Zeggini E, Weedon MN, Frayling TM.
Circulating beta-carotene levels and type 2 diabetes-cause or effect?
Diabetologia. 2009 Oct;52(10):2117-21. PMCID: PMC2746424.

Hennig BJ, Fulford AJ, Sirugo G, Rayco-Solon P, Hattersley AT, Frayling TM, Prentice AM.
FTO gene variation and measures of body mass in an African population.
BMC Med Genet. 2009 Mar 5;10:21.

Perry JR, McCarthy MI, Hattersley AT, Zeggini E; Wellcome Trust Case Control Consortium, Weedon MN, Frayling TM.
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
Diabetes. 2009 Jun;58(6):1463-7.

Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, Perry JR, Pouta A, Ruokonen A, Hyppönen E, Power C, Elliott P, Strachan DP, Järvelin MR, Smith GD, McCarthy MI, Frayling TM, Hattersley AT.
Type 2 diabetes risk alleles are associated with reduced size at birth.
Diabetes. 2009 Jun;58(6):1428-33. Epub 2009 Feb 19.

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O’Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Nat Genet. 2009 Jan;41(1):25-34. Epub 2008 Dec 14.

2008

Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, Scott LJ; DIAGRAM Consortium, Palmer CN, Morris AD, McCarthy MI, Ferrucci L, Hattersley AT, Zeggini E, Frayling TM.
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
Diabetologia. 2008 Dec;51(12):2205-13. Epub 2008 Oct 14.

Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M; RISC Consortium.
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.

Diabetologia. 2008 Nov;51(11):1989-92. Epub 2008 Aug 22.

Frayling TM, Colhoun H, Florez JC. Editorial
A genetic link between type 2 diabetes and prostate cancer.
Diabetologia. 2008 Oct;51(10):1757-60. Epub 2008 Aug 12.

Lango H; UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN.
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
Diabetes. 2008 Nov;57(11):3129-35. Epub 2008 Jun 30.

Perry JR, Frayling TM.
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function.
Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):371-7.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O’Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses’ Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I.
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nat Genet. 2008 Jun;40(6):768-75.

Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L,Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ; Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nat Genet. 2008 May;40(5):638-45.

Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, Lindgren CM, Lango H, Melzer D, Ferrucci L, Paolisso G, Neville MJ, Karpe F, Palmer CN, Morris AD, Elliott P, Jarvelin MR, Smith GD, McCarthy MI, Hattersley AT, Frayling TM.
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
Diabetes. 2008 May;57(5):1419-26.

Frayling TM. Commentary
Genetic association studies see light at the end of the tunnel.
Int J Epidemiol. 2008 Feb;37(1):133-5. Epub 2007 Oct 5.

2007

Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium.
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Diabetes. 2007 Dec;56(12):3101-4.

Frayling TM, McCarthy MI. Editorial
Genetic studies of diabetes following the advent of the genome-wide association study: where do we go from here?
Diabetologia. 2007 Nov;50(11):2229-33.

Timothy M Frayling Review
Genome wide association studies provide new insights into type 2 diabetes aetiology.
Nature Reviews Genetics 2007 Sep;8(9):657-62

Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I.
Common variants in WFS1 confer risk of type 2 diabetes.
Nat Genet. 2007 Aug;39(8):951-3.

Zeggini E*, Weedon MN*, Lindgren CM*, Frayling TM*, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney ASF, The Wellcome Trust Case Control Consortium, McCarthy MI, Hattersley AT.
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Science. 2007 Jun 1;316(5829):1336-41.

Freathy RM, Weedon MN, Bennett A, Hyppönen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, Pembrey ME, Ben-Shlomo Y, Strachan DP, Power C, Jarvelin M-R, McCarthy MI, Davey Smith G, Hattersley AT and Frayling TM.
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
American Journal of Human Genetics. March 2007.

Frayling TM*, Timpson NJ*, Weedon MN*, Zeggini E*, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Davey-Smith G; The Wellcome Trust Case Control Consortium; Hattersley AT, McCarthy MI.
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity.
Science. 2007 May 11;316(5826):889-94

The best from pre-history

Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffery AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Smith GD, Hattersley AT, Di Rienzo A, Frayling TM.
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.
Am J Hum Genet. 2006 Dec;79(6):991-1001.

Weedon MN, McCarthy MI, Hitman GA, Walker M, Groves C, Shields B, Owen KR, Hattersley AT and Frayling TM.
Combining information from multiple common susceptibility polymorphisms increases the predictive power of genetic information: a study of replicated type 2 diabetes variants.
PLoS Medicine, 2006. Oct 3;3(10)

Groves CJ, Zeggini E, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Hattersley AT, McCarthy MI.
Association analysis of 7000 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene capable of doubling diabetes risk.
Diabetes 2. 2006 Sep;55(9):2640-4.

Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L,Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J,Byberg L, Mann V, Axelsson T, Syvanen AC, Leon D, Hattersley AT.
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Diabetes. 2005 Feb;54(2):576-81.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Diabetes. 2003 Feb; 52(2): 568-72.

Minton JA, Hattersley AT, Owen K, McCarthy MI, Walker M, Latif F, Barrett T, Frayling TM. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.
Diabetes. 2002 Apr; 51(4): 1287-90.

Macfarlane WM*, Frayling TM*, Ellard S, Evans JC, Allen LI, Bulman MP, AyresS, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, HattersleyAT.
Missense mutations in the insulin promoter factor-1 gene predispose to type 2diabetes.
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