Type 2 diabetes, obesity, growth & reproductive ageing genetics

REPRODUCTIVE AGEING

Below you can find links to our publications related to reproductive lifespan, led by Dr Anna Murray and Dr Kate Ruth (a.murray@exeter.ac.uk)

2016

Ruth KS, Campbell PJ, Chew S, Lim EM, Hadlow N, Stuckey BG, Brown SJ, Feenstra B, Joseph J, Surdulescu GL, Zheng HF, Richards JB, Murray A, Spector TD, Wilson SG, Perry JR.
Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes.
Eur J Hum Genet. 2016 Feb;24(2):284-90. Epub 2015 May 27. PubMed Central PMCID: PMC4564946.

Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, Murray A.
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
Hum Reprod. 2016 Feb;31(2):473-81. Epub 2016 Jan 4. PubMed Central PMCID: PMC4716809.

2015

Perry JR, Murray A, Day FR, Ong KK.
Molecular insights into the aetiology of female reproductive ageing.
Nat Rev Endocrinol. 2015 Dec;11(12):725-34. Epub 2015 Oct 13. Review. PubMed PMID: 26460341.

Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L,~150 authors, PRACTICAL Consortium; kConFab Investigators; AOCS Investigators; Generation Scotland; EPIC-InterAct Consortium; LifeLines Cohort Study, Price AL, Stefansson K, Visser JA, Ong KK, Chang-Claude J, Murabito JM, Perry JR, Murray A.
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
Nat Genet. 2015. Nov;47(11):1294-303. Epub 2015 Sep 28. PubMed Central PMCID: PMC4661791.

Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C, Huffman ~80 authors, Völzke H, Wareham NJ, Wellons M, Franceschini N, Chasman DI, Thorsteinsdottir U, Murray A, Stefansson K, Murabito JM, Ong KK, Perry JR.
Rare coding variants and X-linked loci associated with age at menarche.
Nat Commun. 2015 Aug 4;6:7756. PubMed Central PMCID: PMC4538850.

Day FR, Elks CE, Murray A, Ong KK, Perry JR.
Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study.
Sci Rep. 2015 Jun 18;5:11208. PubMed Central PMCID: PMC4471670.

2014

Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, ~150 authors, Snieder H, Sørensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK.
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature. 2014 Oct 2;514(7520):92-7. Epub 2014 PubMed Central PMCID: PMC4185210.

Perry JR, Hsu YH, Chasman DI, Johnson AD, Elks C, Albrecht E, Andrulis IL, ~70 authors, ReproGen Consortium, Ong KK, Murabito JM, Karasik D, Murray A.
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.
Hum Mol Genet. 2014 May 1;23(9):2490-7. Epub 2013 Dec 19. PubMed Central PMCID: PMC3976329.

2013

Perry JR, Corre T, Esko T, Chasman DI, Fischer K, Franceschini N, He C, Kutalik Z, Mangino M, Rose LM, Vernon Smith A, Stolk L, Sulem P, Weedon MN, Zhuang WV, Arnold A, Ashworth A, Bergmann S, Buring JE, Burri A, Chen C, Cornelis MC, Couper DJ, Goodarzi MO, Gudnason V, Harris T, Hofman A, Jones M, Kraft P, Launer L, Laven JS, Li G, McKnight B, Masciullo C, Milani L, Orr N, Psaty BM; ReproGen Consortium, Ridker PM, Rivadeneira F, Sala C, Salumets A, Schoemaker M, Traglia M, Waeber G, Chanock SJ, Demerath EW, Garcia M, Hankinson SE, Hu FB, Hunter DJ, Lunetta KL, Metspalu A, Montgomery GW, Murabito JM, Newman AB, Ong KK, Spector TD, Stefansson K, Swerdlow AJ, Thorsteinsdottir U, Van Dam RM, Uitterlinden AG, Visser JA, Vollenweider P, Toniolo D, Murray A.
A genome-wide association study of early menopause and the combined impact of identified
variants.
Hum Mol Genet. 2013 Apr 1;22(7):1465-72. . Epub 2013 Jan 9. PubMed PMID: 23307926; PubMed Central PMCID: PMC3596848.

2012

Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, ~100 authors, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL.
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Nat Genet. 2012 Jan 22;44(3):260-8. PubMed Central PMCID: PMC3288642.

2011

Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JR, Koster A, Petersen AK, Eriksson J, Lehtimäki T, Huhtaniemi IT, Hammond GL, Maggio M, Coviello AD; EMAS Study Group, Ferrucci L, Heier M, Hofman A, Holliday KL, Jansson JO, Kähönen M, Karasik D, Karlsson MK, Kiel DP, Liu Y, Ljunggren O, Lorentzon M, Lyytikäinen LP, Meitinger T, Mellström D, Melzer D, Miljkovic I, Nauck M, Nilsson M, Penninx B, Pye SR, Vasan RS, Reincke M, Rivadeneira F, Tajar A, Teumer A, Uitterlinden AG, Ulloor J, Viikari J, Völker U, Völzke H, Wichmann HE, Wu TS, Zhuang WV, Ziv E, Wu FC, Raitakari O, Eriksson A, Bidlingmaier M, Harris TB, Murray A, de Jong FH, Murabito JM, Bhasin S, Vandenput L, Haring R.
Genetic determinants of serum testosterone concentrations in men.
PLoS Genet. 2011 Oct;7(10):e1002313. Epub 2011 Oct 6. PubMed Central PMCID: PMC3188559.

Murray A, Bennett CE, Perry JR, Weedon MN, Jacobs PA, Morris DH, Orr N, Schoemaker MJ, Jones M, Ashworth A, Swerdlow AJ; ReproGen Consortium.
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.
Hum Mol Genet. 2011 Jan 1;20(1):186-92. Epub 2010 Oct 17. PubMed Central PMCID: PMC3000672.

2010

Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, ~120 authors, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Uitterlinden AG, Widen E, Murabito JM, Ong KK, Murray A.
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Nat Genet. 2010 Dec;42(12):1077-85. PubMed Central PMCID: PMC3140055.

2009

Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM.
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Nat Genet. 2009 Jun;41(6):648-50. Epub 2009 May 17. PubMed Central PMCID: PMC2942986.