Data

Below links to data in our publications, including summary association statistics from genome wide studies:

Wood AR, Jonsson A, Jackson AU, Wang N, van Leewen N, et al. (2017). A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes. DOI: 10.2337/db16-1452

Wood_et_al_2017_AIR_adj_BMI+SI
Wood_et_al_2017_DI_adj_BMI
Wood_et_al_2017_ISR_adj_BMI
Wood_et_al_2017_PEAK_adj_BMI+SI

Fields are as follows:

MARKERNAME = Variant rsid or chr:pos is not available
A1 = Effect allele
A2 = Other allele
FREQ_A1 = Meta-analysis allele frequency for A1
EFFECT_A1 = Beta estimate of allele A1
STDERR = Standard error
P = Association P-value
N = SNP sample size

Note 1: For these meta-analyses, variants only provided if analysed in >= 3 studies.
Note 2: Allele pairs “R” and “A” represent REF and ALT alleles as defined in the imputation reference panel for indels.

If you use these data, please cite the reference above.


 

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H et al. (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLOS Genetics (Accepted). DOI 10.1371/journal.pgen.1006125

Jones_et_al_2016_PLOS_Genetics_Chronotype_SIN.txt.gz
Jones_et_al_2016_PLOS_Genetics_Sleep_Duration_SIN.txt.gz

Fields are as follows:

SNP = Variant RSID from dbSNP (given as “.” if not found in dbSNP)
CHR = Chromosome
BP = Base-pair position (hg19/b37)
ALLELE1 = Effect allele (POS (+) strand)
ALLELE0 = Alternate allele (POS (+) strand)
A1FREQ = Frequency of ALLELE1
BETA = Association test beta corresponding to ALLELE1
SE = Standard error of beta corresponding to ALLELE1
P = Association test P-value
HWE_MLOGP = Minus log10 P-value of HWE test null hypothesis
QUAL = Imputation quality of variant

If you use these data, please cite the reference above.


 

Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth SE et al. (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia DOI 10.1007/s00125-016-3908-5.

bmi_dom_dev.txt.gz
t2d_dom_dev.txt.gz

Each file consists of the following information for each variant and its association under a dominance deviation model  to the specified trait. Statistics for p values, betas and standard errors are limited to two significant digits.

MarkerName: chr:bp (hg19)
rsID: The dbSNP name of the genetic marker
Allele1: The effect allele (hg19 + strand).
Allele2: The other allele (hg19 + strand)
Freq: The allele frequency of Allele1 in the UK Biobank amongst “White British” individuals
Beta/OR: beta / odds ratio
SE: standard error
P: p-value
N: Number of observations

If you use these data, please cite the reference above.


 

Pilling LC, et al. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY). 2016; 8:1–24. PMID: 27015805 

Pilling_et_al_2016_Aging.txt.gz

rsID: dnSNP name of genetic marker, if available
CHR: chromosome
POS_b37: base-pair position on CHR (hg19 / b37)
A1: effect allele (+ strand)
A2: other allele (+ strand)
A1FREQ: allele frequency of A1 in UK Biobank (May 2015-release) amongst “White British” individuals
BETA_top_1_percent: beta of SNP against outcome “at least one parent in top 1% of parents attained age”
SE_top_1_percent: SE of SNP against outcome “at least one parent in top 1% of parents attained age”
P_top_1_percent: P-value of SNP against outcome “at least one parent in top 1% of parents attained age”
BETA_parents_age_death: beta of SNP against outcome “combined parents age at death (z-scored)”
SE_parents_age_death: SE of SNP against outcome “combined parents age at death (z-scored)”
P_parents_age_death: P-value of SNP against outcome “combined parents age at death (z-scored)”
BETA_fathers_age_death: beta of SNP against outcome “father’s age at death”
SE_fathers_age_death: SE of SNP against outcome “father’s age at death”
P_fathers_age_death: P-value of SNP against outcome “father’s age at death”
BETA_mothers_age_death: beta of SNP against outcome “father’s age at death”
SE_mothers_age_death: SE of SNP against outcome “father’s age at death”
P_mothers_age_death: P-value of SNP against outcome “father’s age at death”

If you use these data, please cite the reference above.


 

DATA FROM THE CONSORTIA WE ARE PART OF:

Reprogren
Reprogen GWAS summary statistics

Early Growth Genetics (EGG) Consortuim
EGG GWAS summary statistics